Lactobacillus plantarum vaccine vector expressing hemagglutinin provides protection against H9N2 challenge infection.

@article{Shi2016LactobacillusPV,
  title={Lactobacillus plantarum vaccine vector expressing hemagglutinin provides protection against H9N2 challenge infection.},
  author={Shaohua Shi and Wen-tao Yang and Gui-lian Yang and Xu-ke Zhang and Yu-ying Liu and Lei Zhang and Li-Ping Ye and Jun Hu and Xin Xing and Chong Qi and Yu Li and Chang Wang},
  journal={Virus research},
  year={2016},
  volume={211},
  pages={
          46-57
        }
}
Hemagglutinin (HA) has been demonstrated as an effective candidate vaccine antigen against AIVs. Dendritic cell-targeting peptide (DCpep) can enhance the robustness of immune responses. The purpose of this study was to evaluate whether DCpep could enhance the immune response against H9N2 AIV when utilizing Lactobacillus plantarum NC8 (NC8) to present HA-DCpep in mouse and chicken models. To accomplish this, a mucosal vaccine of a recombinant NC8 strain expressing HA and DCpep that was… CONTINUE READING
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