Lactobacillus plantarum NCIMB8826 ameliorates inflammation of colon and skin in human APOC1 transgenic mice.

@article{Mariman2016LactobacillusPN,
  title={Lactobacillus plantarum NCIMB8826 ameliorates inflammation of colon and skin in human APOC1 transgenic mice.},
  author={Rob Mariman and Esther Reefman and Frans J Tielen and Carla Persoon-Deen and K van de Mark and N Worms and Frits Koning and Lex M Nagelkerken},
  journal={Beneficial microbes},
  year={2016},
  volume={7 2},
  pages={215-25}
}
Genetic predisposition and environmental factors, including the gut microbiota, have been suggested as major factors in the development and progression of atopic dermatitis. Hyperlipidemic human APOC1(+/+) transgenic mice display many features of human atopic dermatitis, such as scaling, lichenification, excoriations, and pruritus, along with a disturbed skin barrier function. Cytokine analysis of serum shows an increase of various pro-inflammatory cytokines, including interleukin (IL)-12p40… CONTINUE READING