Lactitol, a second-generation disaccharide for treatment of chronic portal-systemic encephalopathy

  title={Lactitol, a second-generation disaccharide for treatment of chronic portal-systemic encephalopathy},
  author={Dr. Misael Uribe and Heloisa Toledo and Franz Perez and MSc Florencia Vargas and Sofia Gil BCHem and Guillermo S Garc{\'i}a-Ramos and G P Ravelli and Luis Guevara},
  journal={Digestive Diseases and Sciences},
A double-blind crossover trial was performed to test the therapeutic usefulness and safety of lactitol, a beta-galactoside sorbitol, against lactose in 18 patients with chronic portal-systemic encephalopathy (PSE). The study included four periods: two for washout and two for lactitol and lactose administration. During washout periods, which lasted two weeks each, patients were stabilized with neomycin plus milk of magnesia. Lactitol and lactose were administered during four weeks each. Ten… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 16 references

Erstmalige Anwendung von ZY 15060 in der Behandlung der porto-systemischen Enzephalopathie

J Bircher, M Buehrer, JA Franz, JA Van Velthuijsen
Schweiz Med Wochenschr • 1982
View 1 Excerpt

Similar effect of lactose and lactulose on in vitro fecal ammonia generation and bacterial flora

H Lewis, S Rojas, M Uribe
Gastroenterology 78:1206, • 1980
View 2 Excerpts

Treatment of chronic portal-systemic encephalopathy with lactose in lactase deficient patients

M Uribe, MA Marquez, G Garcia Ramos
Dig Dis Sci 25:924-928, • 1980
View 1 Excerpt

Food additives derived from lactose: lactitol and lactitol palmitate.

Journal of agricultural and food chemistry • 1979
View 1 Excerpt

The two-period cross-over clinical trial.

British journal of clinical pharmacology • 1979
View 2 Excerpts