Lactic acidosis in metformin-treated patients. Prognostic value of arterial lactate levels and plasma metformin concentrations.

@article{Lalau1999LacticAI,
  title={Lactic acidosis in metformin-treated patients. Prognostic value of arterial lactate levels and plasma metformin concentrations.},
  author={Jean-Daniel Lalau and Jonathan Peter Race},
  journal={Drug safety},
  year={1999},
  volume={20 4},
  pages={
          377-84
        }
}
OBJECTIVE The antidiabetic drug metformin has been associated in a small number of patients with lactic acidosis, a serious condition with a poor prognosis. However, because of lack of data, the prognostic significance of hyperlactataemia in metformin-treated patients is not known. METHODS Data were collected from 49 metformin-treated patients with lactic acidosis (arterial lactate level > or = 5 mmol/L and blood pH < or = 7.35) and available plasma metformin concentration data to investigate… CONTINUE READING

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