Lactic acidosis after cardiac surgery is associated with polymorphisms in tumor necrosis factor and interleukin 10 genes.

@article{Ryan2002LacticAA,
  title={Lactic acidosis after cardiac surgery is associated with polymorphisms in tumor necrosis factor and interleukin 10 genes.},
  author={Thomas A. Ryan and Joanna Balding and Eilis M McGovern and John Hinchion and W. Matthews Churchill Livingstone and Zeb Chughtai and Owen Patrick Smith},
  journal={The Annals of thoracic surgery},
  year={2002},
  volume={73 6},
  pages={1905-9; discussion 1910-1}
}
BACKGROUND Lactic acidosis after cardiac surgery is a manifestation of excess cytokine production. Cytokine-related genetic polymorphisms account for variability in cytokine response and may predispose to the development of lactic acidosis after cardiac surgery. METHODS Routine postoperative cardiac surgery patients were studied. Lactic acid levels were greater than 4 mmol/L in study patients and less than 4 mmol/L in controls. Polymerase chain reaction-based techniques were used to examine… CONTINUE READING