Lactic acid production in Saccharomyces cerevisiae is modulated by expression of the monocarboxylate transporters Jen1 and Ady2.

@article{Pacheco2012LacticAP,
  title={Lactic acid production in Saccharomyces cerevisiae is modulated by expression of the monocarboxylate transporters Jen1 and Ady2.},
  author={Antonio Luiz Schalata Pacheco and Gabriel Talaia and Joana S{\'a}-Pessoa and Daniela Bessa and Maria Jos{\'e} Gonçalves and Roxana Falc{\~a}o Moreira and Sandra Paiva and Margarida Casal and Od{\'i}lia Queir{\'o}s},
  journal={FEMS yeast research},
  year={2012},
  volume={12 3},
  pages={375-81}
}
We aimed to manipulate the metabolism of Saccharomyces cerevisiae to produce lactic acid and search for the potential influence of acid transport across the plasma membrane in this process. Saccharomyces cerevisiae W303-1A is able to use l-lactic acid but its production in our laboratory has not previously been detected. When the l-LDH gene from Lactobacillus casei was expressed in S. cerevisiae W303-1A and in the isogenic mutants jen1∆, ady2∆ and jen1∆ ady2∆, all strains were able to produce… CONTINUE READING

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Yeast strains for the production

  • D Porro, MM Bianchi, +4 authors L Alberghina
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