Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-β.

@article{Kottmann2012LacticAI,
  title={Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-β.},
  author={Robert Matthew Kottmann and Ajit A. Kulkarni and Katie A Smolnycki and Elizabeth Lyda and Thinesh Dahanayake and Rami Salibi and Sylvie Honnons and Carolyn A Jones and Nancy G. Isern and Jian Zhi Hu and Steven Nathan and Geraldine M Grant and Richard P Phipps and Patricia J. Sime},
  journal={American journal of respiratory and critical care medicine},
  year={2012},
  volume={186 8},
  pages={740-51}
}
RATIONALE Idiopathic pulmonary fibrosis (IPF) is a complex disease for which the pathogenesis is poorly understood. In this study, we identified lactic acid as a metabolite that is elevated in the lung tissue of patients with IPF. OBJECTIVES This study examines the effect of lactic acid on myofibroblast differentiation and pulmonary fibrosis. METHODS We used metabolomic analysis to examine cellular metabolism in lung tissue from patients with IPF and determined the effects of lactic acid… CONTINUE READING