Lactic acid-induced swelling in C6 glial cells via Na+/H+ exchange.

  title={Lactic acid-induced swelling in C6 glial cells via Na+/H+ exchange.},
  author={D E Jakubovicz and Amira Klip},
  journal={Brain research},
  volume={485 2},
One of the primary consequences of ischemia is tissue acidification due to anaerobic production of lactic acid. Upon reperfusion and recovery of pH, cytotoxic edema often ensues. Na+/H+ exchange, a mechanism involved in the regulation of intracellular pH (pHi), is activated by low intracellular pH, is dependent on extracellular Na+, and is inhibited by low extracellular pH (pH less than 6) or by amiloride. In this study we explore the role of Na+/H+ exchange in cell swelling following… CONTINUE READING

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