Lactic acid does not directly activate hypothalamic-pituitary corticotroph function.

@article{Petrides1999LacticAD,
  title={Lactic acid does not directly activate hypothalamic-pituitary corticotroph function.},
  author={J S Petrides and Patricia Anne Deuster and Gregory P Mueller},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  year={1999},
  volume={220 2},
  pages={100-5}
}
The role that metabolic products play in regulating the hypothalamic-pituitary-adrenal (HPA) axis during strenuous exercise is speculative. This investigation examined the extent to which lactic acid, a major metabolite of anaerobic exercise, directly affects hypothalamic-pituitary function. Specifically, beta-endorphin secretion was measured from AtT-20 (D-16) mouse corticotroph tumor cells treated either acutely (15 min - 180 min) or chronically (1 day - 3 day) with physiologic levels of… CONTINUE READING