Lactational competence and involution of the mouse mammary gland require plasminogen.

  title={Lactational competence and involution of the mouse mammary gland require plasminogen.},
  author={Leif R\oge Lund and S. Frahm Bj\orn and Mark D. Sternlicht and Boye Schnack Nielsen and Helene Solberg and Pernille Autzen Usher and R Osterby and Ib Jarle Christensen and Ross Wentworth Stephens and Thomas H Bugge and Keld Dan\o and Zena Werb},
  volume={127 20},
Urokinase-type plasminogen activator expression is induced in the mouse mammary gland during development and post-lactational involution. We now show that primiparous plasminogen-deficient (Plg(-/-)) mice have seriously compromised mammary gland development and involution. All mammary glands were underdeveloped and one-quarter of the mice failed to lactate. Although the glands from lactating Plg(-/-) mice were initially smaller, they failed to involute after weaning, and in most cases they… CONTINUE READING


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