Lactation-Induced Changes in the Volume of Osteocyte Lacunar-Canalicular Space Alter Mechanical Properties in Cortical Bone Tissue.

@article{Kaya2017LactationInducedCI,
  title={Lactation-Induced Changes in the Volume of Osteocyte Lacunar-Canalicular Space Alter Mechanical Properties in Cortical Bone Tissue.},
  author={Sadullah Kaya and Jelena Basta-Pljakic and Zeynep Seref-Ferlengez and Robert J. Majeska and Lu{\'i}s Cardoso and Timothy G Bromage and Qihong Zhang and Carol R Flach and Richard Mendelsohn and Shoshana Yakar and Susannah Fritton and Mitchell B. Schaffler},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2017},
  volume={32 4},
  pages={
          688-697
        }
}
Osteocytes can remove and remodel small amounts of their surrounding bone matrix through osteocytic osteolysis, which results in increased volume occupied by lacunar and canalicular space (LCS). It is well established that cortical bone stiffness and strength are strongly and inversely correlated with vascular porosity, but whether changes in LCS volume caused by osteocytic osteolysis are large enough to affect bone mechanical properties is not known. In the current studies we tested the… CONTINUE READING
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