Lactate utilization in mitochondria prevents Bax cytotoxicity in yeast Kluyveromyces lactis.

Abstract

In a search for the physiological conditions able to suppress the disruption of electron transport through the inner mitochondrial membrane induced by Bax, we found that respiratory substrate - lactate completely abolished Bax toxicity in yeast Kluyveromyces lactis. The effect of lactate was dependent on the presence of cytochrome c, as no effect was… (More)

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