Lactate transport in heart in relation to myocardial ischemia.

  title={Lactate transport in heart in relation to myocardial ischemia.},
  author={Andrew Philip Halestrap and Xiaohong Wang and Rachael Poole and Vicky N Jackson and Nigel T. Price},
  journal={The American journal of cardiology},
  volume={80 3A},
In this article, the importance of lactic acid transport into and out of heart cells is described and the properties of the monocarboxylate transporters (MCTs) responsible are presented. These are monocarboxylate/proton symporters with a broad substrate specificity that includes L-lactate, pyruvate, and the ketone bodies acetate, acetoacetate, and beta-hydroxybutyrate. Although it is unlikely that lactic acid transport constrains heart metabolism under most conditions, it may do so during… CONTINUE READING