Lactate stimulates vasculogenic stem cells via the thioredoxin system and engages an autocrine activation loop involving hypoxia-inducible factor 1.

@article{Milovanova2008LactateSV,
  title={Lactate stimulates vasculogenic stem cells via the thioredoxin system and engages an autocrine activation loop involving hypoxia-inducible factor 1.},
  author={Tatyana N. Milovanova and Veena M. Bhopale and Elena M. Sorokina and Jonni S. Moore and Thomas K. Hunt and Martin Hauer-Jensen and Omaida C Velazquez and Stephen R. Thom},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 20},
  pages={6248-61}
}
The recruitment and differentiation of circulating stem/progenitor cells (SPCs) in subcutaneous Matrigel in mice was assessed. There were over one million CD34(+) SPCs per Matrigel plug 18 h after Matrigel implantation, and including a polymer to elevate the lactate concentration increased the number of SPCs by 3.6-fold. Intricate CD34(+) cell-lined channels were linked to the systemic circulation, and lactate accelerated cell differentiation as evaluated based on surface marker expression and… CONTINUE READING