Lactate production and pyruvate dehydrogenase activity in fat and skeletal muscle from diabetic rats.

@article{Mondon1992LactatePA,
  title={Lactate production and pyruvate dehydrogenase activity in fat and skeletal muscle from diabetic rats.},
  author={Carl E. Mondon and Ian Jones and Salman Azhar and Clarie B Hollenbeck and Gerald Mark Reaven},
  journal={Diabetes},
  year={1992},
  volume={41 12},
  pages={1547-54}
}
This study was initiated to explore the possibility that an increase in the supply of gluconeogenic precursors contributes to the overproduction of glucose by the liver in NIDDM patients. To address this issue, a form of experimental NIDDM was produced in rats by injecting a low dose (38 mg/kg) of STZ and comparing lactate and alanine production and PDH activity in skeletal muscle and isolated adipocytes from normal and diabetic rats. Skeletal muscle lactate production was measured by using a… CONTINUE READING

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