Lactate fuels the human brain during exercise

@article{Quistorff2008LactateFT,
  title={Lactate fuels the human brain during exercise},
  author={B. Quistorff and N. Secher and J. V. van Lieshout},
  journal={The FASEB Journal},
  year={2008},
  volume={22},
  pages={3443 - 3449}
}
The human brain releases a small amount of lactate at rest, and even an increase in arterial blood lactate during anesthesia does not provoke a net cerebral lactate uptake. However, during cerebral activation associated with exercise involving a marked increase in plasma lactate, the brain takes up lactate in proportion to the arterial concentration. Cerebral lactate uptake, together with glucose uptake, is larger than the uptake accounted for by the concomitant O2 uptake, as reflected by the… Expand
174 Citations
Cerebral glucose and lactate consumption during cerebral activation by physical activity in humans
  • P. Rasmussen, M. Wyss, C. Lundby
  • Medicine, Chemistry
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2011
  • 71
Hypoxia and exercise provoke both lactate release and lactate oxidation by the human brain
  • M. Overgaard, P. Rasmussen, +7 authors N. Secher
  • Chemistry, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2012
  • 64
Three questions to the human brain
Blood Lactate is an Important Energy Source for the Human Brain
  • G. van Hall, Morten Stømstad, +6 authors H. Nielsen
  • Biology, Medicine
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2009
  • 343
  • PDF
Sympathetic influence on cerebral blood flow and metabolism during exercise in humans
  • 89
Lactate uptake by the injured human brain: evidence from an arteriovenous gradient and cerebral microdialysis study.
  • 48
An Ultra-High Field Magnetic Resonance Spectroscopy Study of Post Exercise Lactate, Glutamate and Glutamine Change in the Human Brain
  • 20
  • Highly Influenced
Plasma pH does not influence the cerebral metabolic ratio during maximal whole body exercise
  • 16
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 55 REFERENCES
Increased lactate/pyruvate ratio augments blood flow in physiologically activated human brain.
  • 126
  • PDF
Cerebral Oxygen/Glucose Ratio is Low during Sensory Stimulation and Rises above Normal during Recovery: Excess Glucose Consumption during Stimulation is Not Accounted for by Lactate Efflux from or Accumulation in Brain Tissue
  • P. L. Madsen, N. Cruz, L. Sokoloff, G. Dienel
  • Biology, Medicine
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 1999
  • 154
  • Highly Influential
Cerebral blood flow and metabolism during exercise: implications for fatigue.
  • 314
  • PDF
Influence of Blood Glucose Concentration on Brain Lactate Accumulation during Severe Hypoxia and Subsequent Recovery of Brain Energy Metabolism
  • 116
Cerebral carbohydrate cost of physical exertion in humans.
  • 58
  • PDF
Cerebral ammonia uptake and accumulation during prolonged exercise in humans
  • 101
The CSF and arterial to internal jugular venous hormonal differences during exercise in humans
  • 37
...
1
2
3
4
5
...