Lactate dehydrogenase inhibition by immunoglobulin G in human serum.

@article{Maekawa1986LactateDI,
  title={Lactate dehydrogenase inhibition by immunoglobulin G in human serum.},
  author={M. Maekawa and Kayoko Sudo and Kunihiro Iwahara and Takashi Kanno},
  journal={Clinical chemistry},
  year={1986},
  volume={32 7},
  pages={1347-9}
}
Low lactate dehydrogenase (LD; EC 1.1.1.27) activity and an abnormal LD pattern in electrophoretograms of LD isoenzymes in the sera of two patients were caused by inhibition of LD by immunoglobulin G. One of these showed inhibitor activity in the serum upon direct analysis, while the other showed activity only after the immunoglobulin was stripped from the LD. As judged from the LD isoenzyme patterns in serum, the LD inhibitor appeared to act against M subunits. However, quantification of… CONTINUE READING