Lactate dehydrogenase A silencing in IDH mutant gliomas.

  title={Lactate dehydrogenase A silencing in IDH mutant gliomas.},
  author={Charles Chesnelong and Myriam M. Chaumeil and Michael D Blough and Mohammad Al-Najjar and Owen D. M. Stechishin and Jennifer A W Chan and Russell O. Pieper and Sabrina M. Ronen and Samuel A Weiss and Hema Artee Luchman and J. Gregory Cairncross},
  volume={16 5},
BACKGROUND Mutations of the isocitrate dehydrogenase 1 and 2 gene (IDH1/2) were initially thought to enhance cancer cell survival and proliferation by promoting the Warburg effect. However, recent experimental data have shown that production of 2-hydroxyglutarate by IDH mutant cells promotes hypoxia-inducible factor (HIF)1α degradation and, by doing so, may have unexpected metabolic effects. METHODS We used human glioma tissues and derived brain tumor stem cells (BTSCs) to study the… CONTINUE READING