Lactate and force production in skeletal muscle.

@article{Kristensen2005LactateAF,
  title={Lactate and force production in skeletal muscle.},
  author={Michael Seltz Kristensen and Janni Albertsen and Maria Louise Rentsch and Carsten Juel},
  journal={The Journal of physiology},
  year={2005},
  volume={562 Pt 2},
  pages={
          521-6
        }
}
Lactic acid accumulation is generally believed to be involved in muscle fatigue. However, one study reported that in rat soleus muscle (in vitro), with force depressed by high external K(+) concentrations a subsequent incubation with lactic acid restores force and thereby protects against fatigue. However, incubation with 20 mm lactic acid reduces the pH gradient across the sarcolemma, whereas the gradient is increased during muscle activity. Furthermore, unlike active muscle the Na(+)-K… CONTINUE READING

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