Lactate-activated macrophages induced aerobic glycolysis and epithelial-mesenchymal transition in breast cancer by regulation of CCL5-CCR5 axis: a positive metabolic feedback loop

@inproceedings{Lin2017LactateactivatedMI,
  title={Lactate-activated macrophages induced aerobic glycolysis and epithelial-mesenchymal transition in breast cancer by regulation of CCL5-CCR5 axis: a positive metabolic feedback loop},
  author={Sen-sen Lin and Li Sun and Xiaodan Lyu and Xiongfei Ai and Danyu Du and Nan Su and Hongyang Li and Lu-yong Zhang and Jun Yu and Shengtao Yuan},
  booktitle={Oncotarget},
  year={2017}
}
Aberrant energy metabolism is critical for cancer progression. Tumor-associated macrophages (TAMs) can stimulate tumor angiogenesis and enhance cancer metastasis; however, the metabolic interaction between cancer cells and macrophages characterized by lactate shuttles remains unclear. Here, we showed that lactate activated human macrophages to a TAM-like phenotype and stimulated the secretion of CCL5 by activation of Notch signaling in macrophages. Reciprocally, CCL5 increased cell migration… CONTINUE READING