Lactate: the ultimate cerebral oxidative energy substrate?

  title={Lactate: the ultimate cerebral oxidative energy substrate?},
  author={Avital Schurr},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={26 1},
  • Avital Schurr
  • Published 2006 in
    Journal of cerebral blood flow and metabolism…
Research over the past two decades has renewed the interest in lactate, no longer as a useless end product of anaerobic glycolysis in brain (and other tissues), but as an oxidative substrate for energy metabolism. While this topic would be considered blasphemy only three decades ago, much recent evidence indicates that lactate does play a major role in aerobic energy metabolism in the brain, the heart, skeletal muscle, and possibly in any other tissue and organ. Nevertheless, this concept has… CONTINUE READING
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