Lactate: a preferred fuel for human brain metabolism in vivo.

  title={Lactate: a preferred fuel for human brain metabolism in vivo.},
  author={Diarmuid Smith and Andrew Pernet and William A. Hallett and Emma M Bingham and Paul K. Marsden and Stephanie A. Amiel},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={23 6},
Recent in vitro studies suggest that lactate, rather than glucose, may be the preferred fuel for neuronal metabolism. The authors examined the effect of lactate on global brain glucose uptake in euglycemic human subjects using 18 fluoro-deoxyglucose (FDG) positron emission tomography (PET). Eight healthy men, aged 40 to 54 years, underwent a 60-minute FDG-PET scan on two occasions in random order. On one occasion, 6.72% sodium lactate was infused at a rate of 50 micro mol. kg-1. min-1 for 20… CONTINUE READING
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