Lactate/glucose dynamics after rat fluid percussion brain injury.

  title={Lactate/glucose dynamics after rat fluid percussion brain injury.},
  author={Tao Chen and Y Z Qian and Xiao Ming Di and Ann Rice and Judy P. Q. Zhu and R. R. Bullock},
  journal={Journal of neurotrauma},
  volume={17 2},
Traumatic brain injury (TBI) places enormous early energy demand on brain tissue to reinstate normal ionic balance. Clinical studies have demonstrated a decline in extracellular fluid (ECF) glucose and an increase in lactate after TBI. In vitro studies suggest that this increase in lactate is mediated by increased glutamate and may provide a metabolic substrate for neurons, to aid in ionic restoration. This led us to hypothesize that high ECF lactate may be beneficial in recovery following TBI… CONTINUE READING
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