Lacritin-induced secretion of tear proteins from cultured monkey lacrimal acinar cells.

@article{Fujii2013LacritininducedSO,
  title={Lacritin-induced secretion of tear proteins from cultured monkey lacrimal acinar cells.},
  author={Atsuko Fujii and Ayumi Morimoto-Tochigi and Ryan D. Walkup and Thomas R. Shearer and Mitsuyoshi Azuma},
  journal={Investigative ophthalmology & visual science},
  year={2013},
  volume={54 4},
  pages={2533-40}
}
PURPOSE During inflammation of the ocular surface, increased proinflammatory cytokines depress tear protein secretion, suggesting that a decline in lacrimal cell function contributes to dry eye. Lacritin, a glycoprotein secreted from lacrimal acinar cells, may function as an autocrine factor to stimulate tear protein secretion. The purpose of the present experiment was to investigate lacritin-induced protein secretion in normal and cytokine-pretreated (inflammation model) monkey acinar cells… CONTINUE READING

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