Lacrimo-auriculo-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway.

Abstract

Lacrimo-auriculo-dento-digital (LADD) syndrome is characterized by abnormalities in lacrimal and salivary glands, in teeth, and in the distal limbs. Genetic studies have implicated heterozygous mutations in fibroblast growth factor 10 (FGF10) and in FGF receptor 2 (FGFR2) in LADD syndrome. However, it is not clear whether LADD syndrome mutations (LADD… (More)

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Cite this paper

@article{Shams2007LacrimoauriculodentodigitalSI, title={Lacrimo-auriculo-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway.}, author={Imad Shams and Edyta Rohmann and Veraragavan P. Eswarakumar and Erin Denise Lew and Satoru Yuzawa and Bernd Wollnik and Joseph Schlessinger and Irit Lax}, journal={Molecular and cellular biology}, year={2007}, volume={27 19}, pages={6903-12} }