Lacrimal gland-derived IL-22 regulates IL-17-mediated ocular mucosal inflammation

Abstract

Inflammatory damage of mucosal surface of the eye is a hallmark of dry eye disease (DED) and, in severe cases, can lead to significant discomfort, visual impairment, and blindness. DED is a multifactorial autoimmune disorder with a largely unknown pathogenesis. Using a cross-sectional patient study and a well-characterized murine model of DED, herein we… (More)
DOI: 10.1038/mi.2016.119

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6 Figures and Tables