Lacosamide serum concentrations in adult patients with epilepsy: the influence of gender, age, dose, and concomitant antiepileptic drugs.

@article{Markoula2014LacosamideSC,
  title={Lacosamide serum concentrations in adult patients with epilepsy: the influence of gender, age, dose, and concomitant antiepileptic drugs.},
  author={Sofia Markoula and Rute Teot{\'o}nio and Neville Ratnaraj and John S. Duncan and Josemir W. Sander and Philip N. Patsalos},
  journal={Therapeutic drug monitoring},
  year={2014},
  volume={36 4},
  pages={494-8}
}
OBJECTIVE Lacosamide (LCM), a new antiepileptic drug (AED) approved as adjunctive therapy for the treatment of patients with partial-onset seizures, has limited pharmacokinetic and drug interaction data. The main objectives of the present study were to investigate the effects of dose, age, gender, and hepatic enzyme-inducing AEDs on the pharmacokinetics of LCM as assessed by steady state serum LCM values. METHODS An LCM AED therapeutic drug monitoring database was analyzed with regard to LCM… CONTINUE READING
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Low potential for drug-drug interaction of lacosamide

  • D Thomas, U Scharfenecker, B Schiltmeyer
  • Epilepsia
  • 2006
Highly Influential
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