Lacosamide: pharmacology, mechanisms of action and pooled efficacy and safety data in partial-onset seizures.

@article{Beydoun2009LacosamidePM,
  title={Lacosamide: pharmacology, mechanisms of action and pooled efficacy and safety data in partial-onset seizures.},
  author={Ahmad A Beydoun and Joseph D'souza and David G. Hebert and Pamela Doty},
  journal={Expert review of neurotherapeutics},
  year={2009},
  volume={9 1},
  pages={33-42}
}
Lacosamide is an antiepileptic drug approved in the USA and Europe as adjunctive therapy for partial-onset seizures. Studies suggest that lacosamide selectively enhances slow inactivation of voltage-gated sodium channels and possibly interacts with collapsin response mediator protein-2. The efficacy of lacosamide has been shown in animal models of epilepsy and Phase II/III clinical trials. Pharmacokinetic studies show that it is renally excreted, minimally bound to plasma proteins and has no… CONTINUE READING
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