Lacking of palladin leads to multiple cellular events changes which contribute to NTD

@inproceedings{Tan2017LackingOP,
  title={Lacking of palladin leads to multiple cellular events changes which contribute to NTD},
  author={Juan Tan and Xue-Jiao Chen and Chun-Ling Shen and Hong-xin Zhang and Ling-yun Tang and Shun-yuan Lu and Wen-ting Wu and Ying Kuang and Jian Fei and Zhugang Wang},
  booktitle={Neural Development},
  year={2017}
}
The actin cytoskeleton-associated protein palladin plays an important role in cell motility, morphogenesis and adhesion. In mice, Palladin deficient embryos are lethal before embryonic day (E) 15.5, and exhibit severe cranial neural tube and body wall closure defects. However, the mechanism how palladin regulates the process of cranial neural tube closure (NTC) remains unknown. In this paper, we use gene knockout mouse to elucidate the function of palladin in the regulation of NTC process. We… CONTINUE READING