Lacking applicability of in vitro eye irritation methods to identify seriously eye irritating agrochemical formulations: Results of bovine cornea opacity and permeability assay, isolated chicken eye test and the EpiOcular™ ET‐50 method to classify according to UN GHS

@article{Kolle2017LackingAO,
  title={Lacking applicability of in vitro eye irritation methods to identify seriously eye irritating agrochemical formulations: Results of bovine cornea opacity and permeability assay, isolated chicken eye test and the EpiOcular™ ET‐50 method to classify according to UN GHS},
  author={Susanne Noreen Kolle and Andrew Van Cott and Bennard van Ravenzwaay and Robert Landsiedel},
  journal={Regulatory Toxicology and Pharmacology},
  year={2017},
  volume={85},
  pages={33–47}
}
Abstract In vitro methods have gained regulatory acceptance for the prediction of serious eye damage (UN GHS Cat 1). However, the majority of in vitro methods do not state whether they are applicable to agrochemical formulations. This manuscript presents a study of up to 27 agrochemical formulations tested in three in vitro assays (three versions of the bovine corneal opacity and permeability test (BCOP, OECD TG 437) assay, the isolated chicken eye test (ICE, OECD TG 438) and the EpiOcular™ ET… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

Workshop on acceleration of the validation and regulatory acceptance of alternative methods and implementation of testing strategies.

  • Toxicology in vitro : an international journal published in association with BIBRA
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 22 REFERENCES

Evaluation of the EpiOcular((TM)) Tissue Model as an Alternative to the Draize Eye Irritation Test.

  • Toxicology in vitro : an international journal published in association with BIBRA
  • 1998
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Suitability of the isolated chicken eye test for classification of extreme pH detergents and cleaning products.

  • Toxicology in vitro : an international journal published in association with BIBRA
  • 2015
VIEW 1 EXCERPT