Lack of tumor necrosis factor receptor type 1 inhibits liver fibrosis induced by carbon tetrachloride in mice.

@article{Sudo2005LackOT,
  title={Lack of tumor necrosis factor receptor type 1 inhibits liver fibrosis induced by carbon tetrachloride in mice.},
  author={Kaori Sudo and Yasuhiro Yamada and Hisataka Moriwaki and Kuniaki Saito and Mitsuru Seishima},
  journal={Cytokine},
  year={2005},
  volume={29 5},
  pages={236-44}
}
Chronic liver injury causes liver regeneration, resulting in fibrosis. The proinflammatory cytokine tumor necrosis factor (TNF) is involved in the pathogenesis of many acute and chronic liver diseases. TNF has pleiotropic functions, but its role in liver fibrosis has not been clarified. Chronic repeated injection of CCl4 induces liver fibrosis in mice. We examined whether signaling through TNF receptors was critical for this process, using mice lacking either TNF receptor (TNFR) type 1 or TNFR… CONTINUE READING