Lack of transmission of H5N1 avian–human reassortant influenza viruses in a ferret model

@article{Maines2006LackOT,
  title={Lack of transmission of H5N1 avian–human reassortant influenza viruses in a ferret model},
  author={Taronna R. Maines and Li-mei Chen and Yumiko Matsuoka and Hualan Chen and Thomas Rowe and Juan Ort{\'i}n and Ana Falc{\'o}n and Nguyen Tran Hien and Le Thi Quynh Mai and Endang R. Sedyaningsih and Syahrial Harun and Terrence M. Tumpey and Ruben O. Donis and Nancy J. Cox and Kanta Subbarao and Jacqueline Katz},
  journal={Proceedings of the National Academy of Sciences},
  year={2006},
  volume={103},
  pages={12121 - 12126}
}
Avian influenza A H5N1 viruses continue to spread globally among birds, resulting in occasional transmission of virus from infected poultry to humans. Probable human-to-human transmission has been documented rarely, but H5N1 viruses have not yet acquired the ability to transmit efficiently among humans, an essential property of a pandemic virus. The pandemics of 1957 and 1968 were caused by avian–human reassortant influenza viruses that had acquired human virus-like receptor binding properties… Expand
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References

SHOWING 1-10 OF 34 REFERENCES
Avian Influenza (H5N1) Viruses Isolated from Humans in Asia in 2004 Exhibit Increased Virulence in Mammals
TLDR
The results demonstrate the general equivalence of mouse and ferret models for assessment of the virulence of 2003 and 2004 H5N1 viruses, however, the apparent enhancement ofvirulence of these viruses in humans in 2004 was better reflected in the ferret. Expand
Human and avian influenza viruses target different cell types in cultures of human airway epithelium.
TLDR
It is demonstrated that influenza viruses enter the airway epithelium through specific target cells and that there were striking differences in this respect between human and avian viruses. Expand
Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid-based reverse genetics.
TLDR
This is the first successful attempt to develop an H5N1 vaccine seed virus resembling those used in currently licensed influenza A vaccines with properties that make it a promising candidate for further evaluation in humans. Expand
The Surface Glycoproteins of H5 Influenza Viruses Isolated from Humans, Chickens, and Wild Aquatic Birds Have Distinguishable Properties
TLDR
It is found that changes in both HA and NA may be required for the adaptation of influenza viruses from wild aquatic birds to domestic chickens and raises the possibility that chickens may be a possible intermediate host in zoonotic transmission. Expand
Avian-to-human transmission of the PB1 gene of influenza A viruses in the 1957 and 1968 pandemics.
TLDR
Comparative analysis of deduced amino acid sequences disclosed highly conserved regions in PB1 proteins, which may be key structures required for PB1 activities. Expand
Cooperation between the Hemagglutinin of Avian Viruses and the Matrix Protein of Human Influenza A Viruses
TLDR
The currently prevailing human influenza A viruses might have lost their ability to undergo antigenic shift and therefore are unable to form new pandemic viruses that contain an avian HA, a finding that is of great interest for pandemic planning. Expand
Characterization of a Human H5N1 Influenza A Virus Isolated in 2003
TLDR
The findings portray the HK213 isolate as an aquatic avian influenza A virus without the molecular changes associated with the replication of H5N1 avian viruses in land-based poultry such as chickens. Expand
A pandemic warning?
TLDR
An influenza A virus of the H5N1 subtype has now been identified in a human patient, raising discussions about its potential to spark a new human influenza pandemic. Expand
Family Clustering of Avian Influenza A (H5N1)
To the Editor: The unprecedented epizootic of avian influenza A (H5N1) in Asia poses a serious threat of causing the next global influenza pandemic. H5N1 viruses, to which humans have little or noExpand
Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness.
TLDR
An avian H5N1 influenza A virus was isolated from a tracheal aspirate obtained from a 3-year-old child in Hong Kong with a fatal illness consistent with influenza, causing 87.5 to 100 percent mortality in experimentally inoculated White Plymouth Rock and White Leghorn chickens. Expand
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