Lack of toxicity and persistence in the mouse associated with administration of candidate DNA- and modified vaccinia virus Ankara (MVA)-based HIV vaccines for Kenya.

@article{Hanke2002LackOT,
  title={Lack of toxicity and persistence in the mouse associated with administration of candidate DNA- and modified vaccinia virus Ankara (MVA)-based HIV vaccines for Kenya.},
  author={Tom{\'a}{\vs} Hanke and Andrew J McMichael and Rachel V Samuel and Lindsey A J Powell and Lorraine Mcloughlin and Steven J. Crome and April L Edlin},
  journal={Vaccine},
  year={2002},
  volume={21 1-2},
  pages={
          108-14
        }
}
Toxicity, biodistribution and persistence of candidate HIV vaccines pTHr.HIVA, a recombinant DNA, and MVA.HIVA, a recombinant modified vaccinia virus Ankara, were determined in the Balb/c mouse. The mice were injected with either two doses of intramuscular pTHr.HIVA DNA (50 microg each, separated by an interval of 14 days), two doses of intradermal MVA.HIVA (10(6) plaque-forming units each, separated by an interval of 14 days), or a combination of the two vaccines, each given in two doses, in a… CONTINUE READING
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