Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection

@inproceedings{Chang2010LackOT,
  title={Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection},
  author={Wei-Chuan Chang and Mitchell R. White and Patience Moyo and Sheree McClear and Steffen Thiel and Kevan L Hartshorn and Kazue Takahashi},
  booktitle={BMC Immunology},
  year={2010}
}
Mannose-binding lectin (MBL), a pattern recognition innate immune molecule, inhibits influenza A virus infection in vitro. MBL deficiency due to gene polymorphism in humans has been associated with infection susceptibility. These clinical observations were confirmed by animal model studies, in which mice genetically lacking MBL were susceptible to certain pathogens, including herpes simplex virus 2. We demonstrate that MBL is present in the lung of naïve healthy wild type (WT) mice and that MBL… CONTINUE READING