Lack of the antioxidant enzyme glutathione peroxidase-1 accelerates atherosclerosis in diabetic apolipoprotein E-deficient mice.

@article{Lewis2007LackOT,
  title={Lack of the antioxidant enzyme glutathione peroxidase-1 accelerates atherosclerosis in diabetic apolipoprotein E-deficient mice.},
  author={Paul Lewis and Nada Stefanovic and Josefa Pete and Anna C. Calkin and Sara Giunti and Vicki Thallas-Bonke and Karin Jandeleit-Dahm and Terri Jean Allen and Ismail Kola and Mark Emmanuel Cooper and Judy B de Haan},
  journal={Circulation},
  year={2007},
  volume={115 16},
  pages={2178-87}
}
BACKGROUND Recent clinical studies have suggested a major protective role for the antioxidant enzyme glutathione peroxidase-1 (GPx1) in diabetes-associated atherosclerosis. We induced diabetes in mice deficient for both GPx1 and apolipoprotein E (ApoE) to determine whether this is merely an association or whether GPx1 has a direct effect on diabetes… CONTINUE READING