Lack of the Receptor for Advanced Glycation End-Products Attenuates E. coli Pneumonia in Mice

Abstract

BACKGROUND The receptor for advanced glycation end-products (RAGE) has been suggested to modulate lung injury in models of acute pulmonary inflammation. To study this further, model systems utilizing wild type and RAGE knockout (KO) mice were used to determine the role of RAGE signaling in lipopolysaccharide (LPS) and E. coli induced acute pulmonary… (More)
DOI: 10.1371/journal.pone.0020132

Topics

8 Figures and Tables

Slides referencing similar topics