Lack of the NS5B S282T mutation in HCV isolates from liver tissue of treatment-naive patients with HCV genotype-1b infection.

@article{Maimone2015LackOT,
  title={Lack of the NS5B S282T mutation in HCV isolates from liver tissue of treatment-naive patients with HCV genotype-1b infection.},
  author={Sergio Maimone and Gianluca Tripodi and Cristina Musolino and Irene Cacciola and Teresa Pollicino and Giovanni Raimondo},
  journal={Antiviral therapy},
  year={2015},
  volume={20 2},
  pages={245-7}
}
BACKGROUND Despite the availability of several direct-acting antivirals (DAAs) specifically inhibiting different HCV proteins, treatment of chronic HCV infection is still a challenge also because of the possible selection of resistant viral variants under DAA therapy. Indeed, only the emergence of viruses resistant to the nucleoside inhibitors of the HCV NS5B polymerase (Pol) has not yet been reported, in spite of the fact that in vitro studies have clearly shown that an S282T amino acid change… CONTINUE READING