Lack of the Long Pentraxin PTX3 Promotes Autoimmune Lung Disease but not Glomerulonephritis in Murine Systemic Lupus Erythematosus

@inproceedings{Lech2011LackOT,
  title={Lack of the Long Pentraxin PTX3 Promotes Autoimmune Lung Disease but not Glomerulonephritis in Murine Systemic Lupus Erythematosus},
  author={Maciej Lech and Christoph R{\"o}mmele and Onkar P. Kulkarni and Heni Eka Susanti and Adriana Migliorini and Cecilia Garlanda and Alberto Mantovani and Hans-Joachim Anders},
  booktitle={PloS one},
  year={2011}
}
The long pentraxin PTX3 has multiple roles in innate immunity. For example, PTX3 regulates C1q binding to pathogens and dead cells and regulates their uptake by phagocytes. It also inhibits P-selectin-mediated recruitment of leukocytes. Both of these mechanisms are known to be involved in autoimmunity and autoimmune tissue injury, e.g. in systemic lupus erythematosus, but a contribution of PTX3 is hypothetical. To evaluate a potential immunoregulatory role of PTX3 in autoimmunity we crossed… CONTINUE READING

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