Lack of the COMPASS Component Ccl1 Reduces H3K4 Trimethylation Levels and Affects Transcription of Secondary Metabolite Genes in Two Plant–Pathogenic Fusarium Species

@article{Studt2017LackOT,
  title={Lack of the COMPASS Component Ccl1 Reduces H3K4 Trimethylation Levels and Affects Transcription of Secondary Metabolite Genes in Two Plant–Pathogenic Fusarium Species},
  author={L. Studt and S. Janevska and Birgit Arndt and Stefan Boedi and M. Sulyok and Hans-Ulrich Humpf and B. Tudzynski and J. Strauss},
  journal={Frontiers in Microbiology},
  year={2017},
  volume={7}
}
  • L. Studt, S. Janevska, +5 authors J. Strauss
  • Published 2017
  • Biology, Medicine
  • Frontiers in Microbiology
  • In the two fungal pathogens Fusarium fujikuroi and Fusarium graminearum, secondary metabolites (SMs) are fitness and virulence factors and there is compelling evidence that the coordination of SM gene expression is under epigenetic control. Here, we characterized Ccl1, a subunit of the COMPASS complex responsible for methylating lysine 4 of histone H3 (H3K4me). We show that Ccl1 is not essential for viability but a regulator of genome-wide trimethylation of H3K4 (H3K4me3). Although, recent work… CONTINUE READING
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