Lack of survival benefit of post-operative radiation therapy in prostate cancer patients with positive lymph nodes

Abstract

Randomized data from SWOG 8794 and EORTC 22911 confirm the benefit of post-operative radiation therapy (RT) for selected patients with pT3 prostate cancer (CaP) after radical prostatectomy (RP). However, data regarding the potential benefit of RT for patients post-RP with positive lymph node (+LN) involvement are limited. We analyzed the Surveillance Epidemiology End Results (SEER) registry for population-based data on efficacy of post-operative RT for +LN patients after RP. As LN data have only been captured by SEER since 1988, we analyzed data for 1988–1992, with specific attention to 10-year relative survival (defined as observed survival divided by the survival of a gender-, age- and race-matched population cohort without disease). Specifically analyzed were data for 1921 patients with nonmetastatic prostate cancer who underwent surgery alone, or surgery followed by RT, and who had +LNs documented. SEER does not code the interval between surgery and RT, so the ratio of patients receiving salvage versus adjuvant therapy is unknown. Using follow-up data through 2002, post-diagnosis survival was examined by number of +LNs. There was no significant relative survival benefit for +LN patients receiving post-operative RT (χ2P=0.270). These data do not support routine use of post-operative RT for patients with +LNs in the surgical specimen.

DOI: 10.1038/sj.pcan.4500940

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@article{Johnstone2007LackOS, title={Lack of survival benefit of post-operative radiation therapy in prostate cancer patients with positive lymph nodes}, author={Peter A. S. Johnstone and Vasily J Assikis and Marcel Goodman and Kevin C. Ward and Robert H. Riffenburgh and Viraj A. Master}, journal={Prostate Cancer and Prostatic Diseases}, year={2007}, volume={10}, pages={185-188} }