Lack of robust protective effect of quercetin in two types of 6-hydroxydopamine-induced parkinsonian models in rats and dopaminergic cell cultures.

@article{Kriinen2008LackOR,
  title={Lack of robust protective effect of quercetin in two types of 6-hydroxydopamine-induced parkinsonian models in rats and dopaminergic cell cultures.},
  author={Tiina M. K{\"a}{\"a}ri{\"a}inen and Marjo Piltonen and Bernardino Ossola and Heli Kekki and {\vS}{\'a}rka Lehtonen and Terhi Nenonen and Anne Lecklin and Atso Raasmaja and Pekka T. M{\"a}nnist{\"o}},
  journal={Brain research},
  year={2008},
  volume={1203},
  pages={149-59}
}
In the present study, we examined the ability of a flavonoid quercetin to prevent 6-hydroxydopamine (6-OHDA)-induced oxygen radical formation and cytotoxicity in vitro and neurotoxicity in vivo. Quercetin (10-100 microM) had an acute significant antioxidant effect against the 6-OHDA-induced (30 microM) oxygen radical formation in catecholaminergic SH-SY5Y neuroblastoma cells. Moreover, in these cells, quercetin at 10-50 microM had a significant protective effect against 6-OHDA though at 100… CONTINUE READING
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