Lack of response to multiple genotoxic agents at the hprt locus in peripheral blood T‐lymphocytes of cynomolgus monkeys

@article{Zimmer1999LackOR,
  title={Lack of response to multiple genotoxic agents at the hprt locus in peripheral blood T‐lymphocytes of cynomolgus monkeys},
  author={David M. Zimmer and Philip R. Harbach and S S Mattano and R L Yu and W. B. Mattes and C. S. Aaron},
  journal={Environmental and Molecular Mutagenesis},
  year={1999},
  volume={33}
}
We tested the ability of a series of known genotoxic agents to cause mutations at the hprt locus in peripheral blood T‐lymphocytes of cynomolgus monkeys as measured by the ability to form clones in the presence of 6‐thioguanine. Ethylmethane sulfonate (EMS, 300 mg/kg IP), chloroethylmethane sulfonate (Cl‐EMS, 35 or 50 mg/kg IP), and the Pharmacia & Upjohn antitumor agents adozelesin (1.6, 4, 6, or 8 μg/kg IV) and CC‐1065 (6 μg/kg IV) were all negative in the hprt mutation test. Results with… 
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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