Lack of rapid initiating, promoting or sequential syncarcinogenic effects of di(2-ethylhexyl)phthalate in rat liver carcinogenesis.

@article{Williams1987LackOR,
  title={Lack of rapid initiating, promoting or sequential syncarcinogenic effects of di(2-ethylhexyl)phthalate in rat liver carcinogenesis.},
  author={Gary M Williams and Hiroshi Maruyama and Takuji Tanaka},
  journal={Carcinogenesis},
  year={1987},
  volume={8 7},
  pages={875-80}
}
The effect of prolonged dietary administration of the peroxisome proliferating plasticizer di(2-ethylhexyl)phthalate (DEHP) was studied on liver carcinogenesis initiated by N-2-fluorenylacetamide (FAA) and compared with that of the neoplasm-promoter phenobarbital (PB). Also, DEHP was studied as an initiator by giving it in place of FAA before PB. Male rats were fed FAA for 7 weeks to induce hepatocellular altered foci, and were subsequently given no chemical, 12,000 p.p.m. DEHP or 500 p.p.m. PB… CONTINUE READING

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A systematic review on the adverse health effects of di-2-ethylhexyl phthalate.

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