Lack of protective effect of high-dose ipratropium on bronchoconstriction following exercise with cold air breathing in patients with mild asthma.

@article{Poppius1986LackOP,
  title={Lack of protective effect of high-dose ipratropium on bronchoconstriction following exercise with cold air breathing in patients with mild asthma.},
  author={H. Poppius and Anssi R. A. Sovij{\"a}rvi and Lauri Tammilehto},
  journal={European journal of respiratory diseases},
  year={1986},
  volume={68 5},
  pages={319-25}
}
To evaluate the preventive effect of inhaled ipratropium powder on low-grade bronchoconstriction elicited by breathing cold air during exercise, we subjected 10 adult patients with mild asthma to four identical treadmill exercise tests. The temperature of inhaled air during exercise was -9 +/- 1 degree C. Sixty minutes before exercise, the patients inhaled either placebo or 0.2, 1, or 2 mg of ipratropium powder according to a cross-over, double-blind arrangement. The mean post-exercise fall… CONTINUE READING