Lack of promoting effect of titanium dioxide particles on chemically-induced skin carcinogenesis in rats and mice.

@article{Sagawa2012LackOP,
  title={Lack of promoting effect of titanium dioxide particles on chemically-induced skin carcinogenesis in rats and mice.},
  author={Yoko Sagawa and Mitsuru Futakuchi and Jiegou Xu and Katsumi Fukamachi and Yuto Sakai and Yoshiaki Ikarashi and Tetsuji Nishimura and Masumi Suzui and Hiroyuki Tsuda and Akimichi Morita},
  journal={The Journal of toxicological sciences},
  year={2012},
  volume={37 2},
  pages={317-27}
}
Nano-sized titanium dioxide particles (TiO(2)) are widely used in cosmetics, sunscreens and food additives. We previously reported that topical application of non-coated rutile type TiO(2) did not exhibit a promoting effect on ultraviolet B-initiated skin carcinogenesis in rats, and that this was likely due to lack of penetration of TiO(2) into the epidermis. In the present study, we examined the promoting effect of silicone coated TiO(2 )(sTiO(2)) suspended in silicone oil and non-coated TiO(2… CONTINUE READING
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