Lack of prognostic and predictive value of CA IX in radiotherapy of squamous cell carcinoma of the head and neck with known modifiable hypoxia: an evaluation of the DAHANCA 5 study.

@article{Eriksen2007LackOP,
  title={Lack of prognostic and predictive value of CA IX in radiotherapy of squamous cell carcinoma of the head and neck with known modifiable hypoxia: an evaluation of the DAHANCA 5 study.},
  author={Jesper Grau Eriksen and Jens Overgaard},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2007},
  volume={83 3},
  pages={383-8}
}
BACKGROUND AND PURPOSE CA IX is suggested to be an endogenous marker of hypoxia in tumours like squamous cell carcinomas of the head and neck (HNSCC). The aim of the present study was to investigate whether CA IX served as a prognostic factor for outcome in a large population of HNSCC and if CA IX was able to discriminate the tumours that did benefit from hypoxic modification with nimorazole. MATERIALS AND METHODS Paraffin-embedded formalin-fixed pre-treatment tumour tissue was available from… CONTINUE READING