Lack of production of the 19-kDa glycolipoprotein in certain strains of Mycobacterium tuberculosis.

@article{Lathigra1996LackOP,
  title={Lack of production of the 19-kDa glycolipoprotein in certain strains of Mycobacterium tuberculosis.},
  author={Raju Lathigra and Yi-zheng Zhang and Mark L Hill and Mar{\'i}a Jes{\'u}s Garc{\'i}a and Paul Jackett and Juraj Iv{\'a}nyi},
  journal={Research in microbiology},
  year={1996},
  volume={147 4},
  pages={237-49}
}
The 19-kDa glycolipoprotein of Mycobacterium tuberculosis (PT19) is a prominent antigen recognized by both T cells and antibodies from tuberculosis patients. We report here that two strains, I2646 and S1, when grown either in bacteriological culture or during infection of mice, do not produce this constituent, as judged by ELISA and Western blot assays. Southern blot analysis of the chromosomal DNA showed that both strains displayed the restriction fragment as in H37Rv DNA, suggesting the lack… CONTINUE READING

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