Lack of plasminogen does not alter the early inflammatory response following a tympanic membrane perforation: a study in plasminogen-deficient mice.

@article{Prestwich2008LackOP,
  title={Lack of plasminogen does not alter the early inflammatory response following a tympanic membrane perforation: a study in plasminogen-deficient mice.},
  author={Annika Hansson Prestwich and Jinan Li and Per Olof Eriksson and Tor Ny and Diana Berggren and Sten Olof Hellstr{\"o}m},
  journal={Acta oto-laryngologica},
  year={2008},
  volume={128 12},
  pages={1294-302}
}
CONCLUSIONS The results of the present study show that the early inflammatory response in plasminogen (plg)-deficient mice is not altered compared to that in wild-type (wt) mice. Therefore the chronicity of the perforation in the long-term healing experiment cannot be explained by an impairment of the early inflammatory response, but rather by an impairment in activation of the inflammatory cells. These findings give further insight into the mechanisms resulting in a clinically seen chronic… CONTINUE READING
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