Lack of phospholipase C-delta1 induces skin inflammation.

  title={Lack of phospholipase C-delta1 induces skin inflammation.},
  author={Manabu Ichinohe and Yoshikazu Nakamura and Kentaro Sai and Masamichi Nakahara and Hideki Yamaguchi and Kiyoko Fukami},
  journal={Biochemical and biophysical research communications},
  volume={356 4},
Phospholipase C (PLC) is a key enzyme in phosphoinositide signaling. We previously generated PLC-delta1 knockout (KO) mice and found that these mice showed remarkable hair loss caused by abnormalities in hair follicle structures. Here we show that the skin of PLC-delta1 KO mice displays typical inflammatory phenotypes, including increased dermal cellularity, leukocyte infiltration, and expression of pro-inflammatory cytokines. In addition, exogenously expressed PLC-delta1 attenuates… CONTINUE READING


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