Lack of phospholipase C-delta1 induces skin inflammation.

@article{Ichinohe2007LackOP,
  title={Lack of phospholipase C-delta1 induces skin inflammation.},
  author={Manabu Ichinohe and Yoshikazu Nakamura and Kentaro Sai and Masamichi Nakahara and Hideki Yamaguchi and Kiyoko Fukami},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={356 4},
  pages={912-8}
}
Phospholipase C (PLC) is a key enzyme in phosphoinositide signaling. We previously generated PLC-delta1 knockout (KO) mice and found that these mice showed remarkable hair loss caused by abnormalities in hair follicle structures. Here we show that the skin of PLC-delta1 KO mice displays typical inflammatory phenotypes, including increased dermal cellularity, leukocyte infiltration, and expression of pro-inflammatory cytokines. In addition, exogenously expressed PLC-delta1 attenuates… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

PLCε signaling in cancer

Journal of Cancer Research and Clinical Oncology • 2015
View 2 Excerpts

Similar Papers

Loading similar papers…