Lack of pharmacokinetic interaction of carbamazepine with tranylcypromine.

  title={Lack of pharmacokinetic interaction of carbamazepine with tranylcypromine.},
  author={Russell T. Joffe and Robert M. Post and Thomas W Uhde},
  journal={Archives of general psychiatry},
  volume={42 7},
To the Editor.— Carbamazepine, a tricyclic compound routinely used in the treatment of epilepsy and trigeminal neuralgia, is also effective in the short-term and prophylactic treatment of bipolar affective disorder. 1 As the clinical use of carbamazepine increases, it is likely that it will be used in combination with a variety of psychotropic agents, including lithium carbonate, other antidepressants, and monoamine oxidase inhibitors. There have been several reports of a marked rise in serum… 

Clinical issues in the use of carbamazepine in psychiatry: a review

  • M. Elphick
  • Medicine, Psychology
    Psychological Medicine
  • 1989
Evidence is presented here in support of the efficacy of carbamazepine (CBZ) in a variety of different psychiatric conditions, and it may possibly be more appropriately prescribed to control or prevent these symptoms than as a treatment for a particular disease entity.

60 Years of Combining Tranylcypromine

A relevant body of evidence shows that tranylcypromine combined with first- and second- generation antipsychotics seems relatively safe and might have beneficial effects in some patients with depressive disorders, although caution is needed with some second-generation antipsychotic that have proserotonergic activity.

Carbamazepine in Psychiatry: A Review

  • M. IsraelP. Beaudry
  • Psychology, Medicine
    Canadian journal of psychiatry. Revue canadienne de psychiatrie
  • 1988
Carbamazepine is a tricyclic compound structurally related to imipramine that has been used since the 1960's for the treatment of trigeminal neuralgias and then approved as an anticonvulsant in the

Clinical use of carbamazepine for bipolar disorders

The chemistry, pharmacodynamics and pharmacokinetics of CBZ are reviewed, as well as reviews of the controlled trials ofCBZ in acute bipolar mania, acute bipolar depression and bipolar maintenance treatment.

Tranylcypromine in mind (Part I): Review of pharmacology

The use of anticonvulsants to augment antidepressant medication.

It is concluded that low-dose combination of classical antidepressants and mood stabilizers appears to be well tolerated and highly effective.

A Systematic Review of Available Evidence

A relevant body of evidence shows that tranylcypromine combined with first and secondgeneration antipsychotics seems relatively safe and might have beneficial effects in some patients with depressive disorders, although caution is needed with some second-generation antippsychotics that have proserotonergic activity.

Interaktionen zwischen Antiepileptika und Psychopharmaka

It is crucial to know about possible drug interactions as they may lead both to impaired effectiveness and to uncontrolled toxicity of specific drugs.



Carbamazepine-isoniazid interaction.

  • S. Block
  • Medicine, Psychology
  • 1982
Manifestations of carbamazepine toxicity include aplastic anemia, rashes, stomatitis, dizziness, diplopia, confusion, headache, anorexia, and nausea.

Combined use of tricyclic antidepressants and monoamine oxidase inhibitors.

  • M. Lader
  • Psychology, Medicine
    The Journal of clinical psychiatry
  • 1983
Combined treatment with tricyclic antidepressants and MAO inhibitors has been an area of some controversy and further controlled clinical studies are clearly needed before combined therapy can be recommended for routine clinical use.

Effect of erythromycin on carbamazepine kinetics

Clearance of oral carbamazepine was lower in the presence of erythromycin, indicating that further clinical studies are warranted, and the decrease in clearance of oral carbsepine secondary to eryhromycin indicates that furtherclinical studies are needed.

Isoniazid-induced carbamazepine toxicity and vice versa: a double drug interaction.

Peytoin intoxication develops in some patients with the slow-acetylator phenotype when isoniazid, a drug used in the treatment of tuberculosis, is given to patients receiving phenytoin.

The Pharmacological Basis of Therapeutics

On pharmacology and the rational use of drugs, 42 authors share the herculean task of reviewing the flood of recent literature under single or dual authorship and each chapter offers a complete and up-to-date review.

Carbamazepine intoxication caused by interaction with isoniazid.

Treatment, including right lumbar sympathetic blockade and catheter dilatation of the right superficial femoral and popliteal arteries, restored peripheral pulses and perfusion in three days and clinical and electromyographic evidence of right common peroneal and tibial neuropathies persisted.