Lack of pharmacokinetic interaction of carbamazepine with tranylcypromine.

@article{Joffe1985LackOP,
  title={Lack of pharmacokinetic interaction of carbamazepine with tranylcypromine.},
  author={Russell T. Joffe and Robert M. Post and Thomas W Uhde},
  journal={Archives of general psychiatry},
  year={1985},
  volume={42 7},
  pages={
          738
        }
}
To the Editor.— Carbamazepine, a tricyclic compound routinely used in the treatment of epilepsy and trigeminal neuralgia, is also effective in the short-term and prophylactic treatment of bipolar affective disorder. 1 As the clinical use of carbamazepine increases, it is likely that it will be used in combination with a variety of psychotropic agents, including lithium carbonate, other antidepressants, and monoamine oxidase inhibitors. There have been several reports of a marked rise in serum… 

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Evidence is presented here in support of the efficacy of carbamazepine (CBZ) in a variety of different psychiatric conditions, and it may possibly be more appropriately prescribed to control or prevent these symptoms than as a treatment for a particular disease entity.

60 Years of Combining Tranylcypromine

A relevant body of evidence shows that tranylcypromine combined with first- and second- generation antipsychotics seems relatively safe and might have beneficial effects in some patients with depressive disorders, although caution is needed with some second-generation antipsychotic that have proserotonergic activity.

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Carbamazepine is a tricyclic compound structurally related to imipramine that has been used since the 1960's for the treatment of trigeminal neuralgias and then approved as an anticonvulsant in the

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The chemistry, pharmacodynamics and pharmacokinetics of CBZ are reviewed, as well as reviews of the controlled trials ofCBZ in acute bipolar mania, acute bipolar depression and bipolar maintenance treatment.

Tranylcypromine in mind (Part I): Review of pharmacology

The use of anticonvulsants to augment antidepressant medication.

It is concluded that low-dose combination of classical antidepressants and mood stabilizers appears to be well tolerated and highly effective.

A Systematic Review of Available Evidence

A relevant body of evidence shows that tranylcypromine combined with first and secondgeneration antipsychotics seems relatively safe and might have beneficial effects in some patients with depressive disorders, although caution is needed with some second-generation antippsychotics that have proserotonergic activity.

Interaktionen zwischen Antiepileptika und Psychopharmaka

It is crucial to know about possible drug interactions as they may lead both to impaired effectiveness and to uncontrolled toxicity of specific drugs.

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